Neutraliserende antistof
 Sædvanlig repræsentation af antistof | |
| Egenskaber | |
|---|---|
| Proteintype | Immunglobulin |
| Funktion | Neutralisering af antigener |
| Produktion | B-celler[1][2] |
Et neutraliserende antistof (NAb) er et antistof, der forsvarer en celle mod en patogen eller infektiøs partikel ved at neutralisere en biologisk virkning den måtte have, således at den ikke længere er infektiøs eller patogen.[3] Neutraliserende antistoffer er en del af det erhvervede eller adaptive immunsystems humorale respons mod virus, intracellulære bakterier og mikrobiel toksin.
Ved at binde specifikt til overfladestrukturer (antigener) på en infektiøs partikel forhindrer neutraliserende antistoffer partiklen i at interagere med de værtsceller den kunne inficere og ødelægge. Immunitet baseret på neutraliserende antistoffer kaldes også steriliserende immunitet, da immunsystemet eliminerede den infektiøse partikel, før nogen infektion fandt sted.[4]
Referencer
- ^ Mike Recher; Karl S Lang; Lukas Hunziker; Stefan Freigang; Bruno Eschli; Nicola L Harris; Alexander Navarini; Beatrice M Senn; Katja Fink; Marius Lötscher; Lars Hangartner; Raphaël Zellweger; Martin Hersberger; Alexandre Theocharides; Hans Hengartner; Rolf M Zinkernagel (8. august 2004). "Deliberate removal of T cell help improves virus-neutralizing antibody production". Nature Immunology. 5 (9): 934-942. doi:10.1038/ni1102. PMID 15300247.
- ^ (Denne henvisning bør kontrolleres) :Stachowiak, Julie (15. august 2008). "Neutralizing Antibodies and Disease-Modifying Therapies for Multiple Sclerosis". About.com. Arkiveret fra originalen 4. maj 2010. Hentet 13. juni 2009.
- ^ "Neutralising antibody". Biology-Online. 2008. Hentet 2009-07-04.
- ^ Dutta, A; Huang, CT; Lin, CY; Chen, TC; Lin, YC; Chang, CS; He, YC (6. september 2016). "Sterilizing immunity to influenza virus infection requires local antigen-specific T cell response in the lungs". Scientific Reports. 6: 32973. Bibcode:2016NatSR...632973D. doi:10.1038/srep32973. PMC 5011745. PMID 27596047.
Eksterne henvisninger
- "Antistoffer" hos Den Store Danske af Jesper Zeuthen og Vagn Andersen
- "Immunologi" hos Den Store Danske af Klaus Bendtzen
- "Immunglobulin" hos Sundhed.dk
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Antistof.JPG
Illustration af antigener og et antistof.
Illustration af antigener og et antistof.
SARS-CoV-2 without background.png
This illustration, created at the Centers for Disease Control and Prevention (CDC), reveals ultrastructural morphology exhibited by coronaviruses. Note the spikes that adorn the outer surface of the virus, which impart the look of a corona surrounding the virion, when viewed electron microscopically. A novel coronavirus, named Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19).
This illustration, created at the Centers for Disease Control and Prevention (CDC), reveals ultrastructural morphology exhibited by coronaviruses. Note the spikes that adorn the outer surface of the virus, which impart the look of a corona surrounding the virion, when viewed electron microscopically. A novel coronavirus, named Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), was identified as the cause of an outbreak of respiratory illness first detected in Wuhan, China in 2019. The illness caused by this virus has been named coronavirus disease 2019 (COVID-19).