Fåresygevirus

Elektronmikroskopi. MuV virioner kan have størrelser fra 90 til 600 nm i diameter

Fåresyge-virus eller Mumps orthorubulavirus, MuV, der tidligere blev kaldt Mumps rubulavirus, tilhører virusfamilien Paramyxoviridae, virusslægten Rubulavirus. MuV er nært beslægtet med og deler mange karakteristika med mæslingevirus.

MuV forårsager fåresyge, dvs. betændelse af spytkirtlerne, eventuelt meningitis (hjernehindebetændelse), encephalitis (hjernebetændelse) og døvhed, eventuelt nedsat frugtbarhed eller sterilitet hvis testiklerne bliver angrebet.[1][2]

Genom

MuV er en membrankappet virus med et genom af negativt polariseret enkeltstrænget RNA (-ssRNA) med 15.384 baser og 8 gener.

Proteiner

  • nucleoprotein (NP)
  • RNA polymerase RNA-afhængig RNA polymerase, RdRp, phosphoprotein (P)
  • V protein
  • I protein,
  • matrix protein (M)
  • fusion protein (F) ,
  • small hydrophobic protein (SH)
  • hemagglutinin-neuraminidase (HN)
  • large protein (L) [3]

Receptor

Receptoren for MuV er fortrinsvis et trisakkarid med α2,3-linked sialinsyre på overfladen af værtsorganismens celler.

Vaccine

MFR-vaccinen er en kombinationsvaccine indført i 1987 med svækkede virus mod mæslinger, fåresyge og røde hunde.


Henvisninger

  1. ^ Mumps Virus. Netter’s Infectious Diseases, 2012
  2. ^ "Rubellavirus. ViralZone". Arkiveret fra originalen 5. december 2019. Hentet 30. april 2020. 
  3. ^ Identification of mumps virus protein and lipid composition by mass spectrometry. Virol. J. 2016

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Mumps virus, negative stained TEM 8758 lores.jpg

ID#: 8758 Description: This 1973 negative stained transmission electron micrograph (TEM) depicted the ultrastructural features displayed by the mumps virus. The mumps virus replicates in the upper respiratory tract and is spread through direct contact with respiratory secretions or saliva or through fomites, i.e., inanimate objects that are contaminated by the virus, and are subsequently handled. The infectious period or time that an infected person can transmit mumps to a non-infected person is from 3 days before symptoms appear to about 9 days after the symptoms appear. The incubation time, which is the period from when a person is exposed to virus to the onset of any symptoms, can vary from 16 to 18 days (range 12-25 days).

Content Providers(s): CDC/ Dr. F. A. Murphy Creation Date: 1973

Copyright Restrictions: None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.