CDKN2A

CDKN2A
Tilgængelige strukturer PDB Ortologsøgning: PDBe RCSB Liste over PDB-idkoder 2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
Identifikatorer
Aliaser	CDKN2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16
External IDs	OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A
Genetisk-relaterede sygdomme
melanoma-pancreatic cancer syndrome[1]
Genontologi Molekylær funktion • NF-kappaB binding • GO:0001948, GO:0016582 proteinbinding • cyclin-dependent protein serine/threonine kinase inhibitor activity • protein kinase binding • RNA binding • DNA binding • p53 binding • transcription factor binding • MDM2/MDM4 family protein binding • ubiquitin-protein transferase inhibitor activity • SUMO transferase activity • disordered domain specific binding • GO:0090645, GO:0061637 ubiquitin ligase inhibitor activity Cellulær komponent • cytoplasma • cytosol • senescence-associated heterochromatin focus • Cellekerne • nuclear body • nucleoplasm • Kernelegeme • Mitokondrie • GO:0009327 protein-containing complex Biologisk proces • positive regulation of smooth muscle cell apoptotic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • replicative senescence • G1 phase • negative regulation of cell-matrix adhesion • cellular senescence • negative regulation of cell growth • positive regulation of cellular senescence • positive regulation of macrophage apoptotic process • cell cycle • Ras protein signal transduction • negative regulation of phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • negative regulation of cell population proliferation • G1/S transition of mitotic cell cycle • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • GO:0097285 Apoptose • regulation of G2/M transition of mitotic cell cycle • GO:0009373 regulation of transcription, DNA-templated • regulation of protein stability • negative regulation of immature T cell proliferation in thymus • regulation of protein export from nucleus • negative regulation of protein kinase activity • negative regulation of proteolysis involved in cellular protein catabolic process • protein K63-linked ubiquitination • positive regulation of signal transduction by p53 class mediator • somatic stem cell division • protein stabilization • protein polyubiquitination • positive regulation of protein sumoylation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • autophagy of mitochondrion • apoptotic mitochondrial changes • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of ubiquitin-protein transferase activity • positive regulation of apoptotic process • rRNA processing • negative regulation of ubiquitin-dependent protein catabolic process • mitochondrial depolarization • positive regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of B cell proliferation • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of apoptotic DNA fragmentation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of protein localization to nucleus • protein sumoylation • GO:1901313 positive regulation of gene expression • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity • amyloid fibril formation • negative regulation of protein neddylation Sources:Amigo / QuickGO
RNA-udtryksmønster
(c) Genomics Institute of the Novartis Research Foundation, CC BY-SA 3.0 (c) Genomics Institute of the Novartis Research Foundation, CC BY-SA 3.0 (c) Genomics Institute of the Novartis Research Foundation, CC BY-SA 3.0
Flere henvisninger til udtrykdata
Ortologer
Art	Menneske	Mus
Entrez	1029	12578
Ensembl	ENSG00000147889	ENSMUSG00000044303
UniProt	P42771 Q8N726	P51480 Q64364
RefSeq (mRNA)	NM_000077 NM_001195132 NM_058195 NM_058196 NM_058197 NM_001363763	NM_001040654 NM_009877
RefSeq (protein)	NP_000068 NP_001182061 NP_478102 NP_478104 NP_001350692 NP_478102.2	NP_001035744 NP_034007 NP_034007.1
Location (UCSC)	n/a	Chr 4: 89.19 – 89.21 Mb
PubMed-søgning	[2]	[3]
Wikidata
Vis/Rediger Menneske Vis/Rediger Mus

CDKN2A, også kendt som cyclin-dependent kinase Inhibitor 2A, er et gen, der i mennesker er placeret i kromosom 9, bånd p21.3.^[4] Det er allestedsnærværende udtrykt i mange typer væv og celler.^[5] Genet koder for to proteiner, heriblandt p16 (eller p16INK4a) og p14arf.^[6] Begge fungerer som tumorsuppressorer ved at regulere cellecyklussen.

Henvisninger

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