GPCR in membrane

Forfatter/Opretter:

Repapetilto

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Kredit:

Eget arbejde

Shortlink:

https://dkwiki.dk/b/1ccf4

kilde:

Wikimedia Commons

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beskrivelse:

This Cartoon depicts a generic GPCR as it may be found within the plasma membrane localized to a lipid raft. It is a 2-dimensional schematic highlighting select structural features that are important to the biological function of many different GPCRs.

Abbreviations, etc:

Branched N-glycan

Filled black Squares= N-acetylglucosamine

Unfilled Circles= Mannose

Each circle making up the long chain represents an amino acid. The peptide motifs are represented by filled circles and labeled using commonly accepted single-letter abbreviations for each amino acid.

N= Asparagine,

x= any amino acid,

S/T= Serine or Threonine,

C= Cysteine (attached S represents an oxidized sulfhydryl group),

E/D= Glutamate or Aspartate,

Y=Tyrosine,

R/K= Arginine or Lysine

GPCR domains:

IL-1 to IL-3= Intracellular loops 1-3

EL-1 to EL-3= Extracellular loops 1-3

Other Proteins:

G-alpha= Alpha subunit of a heterotrimeric G-protein

G-beta/gamma= G-beta/gamma heterodimer of heterotrimeric G-protein

PKC= Protein Kinase C

PKA= Protein Kinase A

GRK= G-protein Coupled Receptor Kinase (GPCR kinase)

Final note: The consensus sequence for PKC phosphorylation is written in the legend from C to N terminus, while the other motifs are all shown as N to C. Actually Im not sure if this matters or not...

Licens:

CC BY-SA 3.0

Licensbetingelser:

Creative Commons Attribution-Share Alike 3.0