MiRNA mechanisms

Forfatter/Opretter:

A. Zinovyev, N. Morozova, A. N. Gorban, A. Harel-Belan

Attribution:

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Kredit:

Mathematical modeling of microRNA-mediated mechanisms of translation repression, arXiv:1202.1243v2 [q-bio.MN]

Shortlink:

https://dkwiki.dk/b/1bdc7

kilde:

Wikimedia Commons

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3100 x 2330 Pixel (466686 Bytes)

beskrivelse:

Interaction of microRNA with protein translation process. Several (from nine documented) mechanisms of translation repression are shown: M1) on the initiation process, preventing assembling of the initiation complex or recruiting the 40S ribosomal subunit; M2) on the ribosome assembly; M3) on the translation process; M7, M8) on the degradation of mRNA. There exist other mechanisms of microRNA action on protein translation (transcriptional, transport to P-bodies, ribosome drop-off, co-translational protein degradation and others) that are not visualized here. Here, 40S and 60S are light and heavy components of the ribosome, 80S is the assembled ribosome bound to mRNA, eIF4F is an translation initiation factor, PABC1 is the Poly-A binding protein, and "cap" is the mRNA cap structure needed for mRNA circularization (which can be the normal m7G-cap or artificial modified A-cap). The initiation of mRNA can proceed in a cap-independent manner, through recruiting 40S to IRES (Internal Ribosome Entry Site) located in 5’UTR region. The actual work of RNA silencing is performed by RISC (RNA-induced silencing complex) in which the main catalytic subunit is one of the Argonaute proteins (AGO), and miRNA serves as a template for recognizing specific mRNA sequences.

Licens:

CC BY 3.0

Licensbetingelser:

Creative Commons Attribution 3.0