MiRNA-biogenesis

Forfatter/Opretter:

Narayanese (talk)

Kredit:

Eget arbejde (Original text: I created this work entirely by myself.)

References:

• Esquela-Kerscher A, Slack FJ (2006) Oncomirs — microRNAs with a role in cancer. Nat Rev Cancer 6: 259–69. PubMed
• Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC (2007) The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 130: 89–100. PubMed

Shortlink:

https://dkwiki.dk/b/1bdb7

kilde:

Wikimedia Commons

størrelse:

1520 x 1610 Pixel (356456 Bytes)

beskrivelse:

Overview of microRNA processing in animals, from transcription to the formation of the effector complex. There are two pathways, one for microRNAs from independent genes and one for intronic microRNAs.

Enzymes in the picture:
Drosha, Pasha (pri-miRNA → pre-miRNA)
Spliceosome (pre-mRNA → intron lariat)
Debranching enzyme (intron lariat → RNA that can fold into pre-miRNA)
RAN-GTP, Exportin-5 (export from nucleus)
Dicer (pre-miRNA → miRNA)

Abbrevations:
pri-miRNA = primary microRNA transcript
pre-mRNA = precursor messenger RNA
pre-miRNA = precursor microRNA
miRNA = microRNA
miRNA* = antisense microRNA
miRNP = microRNA ribonucleoprotein

Licens:

CC BY-SA 3.0

Licensbetingelser:

Creative Commons Attribution-Share Alike 3.0